Info
| ID | 5087 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | PytMP-Ir |
| SMILES | Cc1ccc2nc3c4ncccc4c4nc5cc(C)c(C)cc5nc4c3n2c1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C45H33IrN7/(1-57)(2-42)(3-39)(4-51)(5-65)(6-49)(7-50)(8-40)(9-54)(10-68)(11-43)(12-52)(13-48)(14-44)(15-66)(16-35)(17-47)(18-35)(19-36)(20-36)(21-34)(22-58)(23-55)(24-56)(25-46)(26-53)(27-36)(28-34)(29-34)(30-41)(31-67)(32-45)(33-35)(34-63)(35-61)(36-60)(37-39)(37-59)(38-51)(38-64)(39-40)(40-43)(41-55)(41-69)(42-43)(42-59)(44-48)(44-64)(45-56)(45-72)(46-47)(46-61)(47-78)(48-54)(49-55)(49-65)(50-56)(50-66)(51-54)(52-57)(52-68)(53-60)(53-77)(57-62)(58-63)(58-74)(59-69)(60-63)(61-67)(62-70)(62-75)(64-72)(65-82)(66-83)(67-81)(68-84)(69-82)(70-71)(70-84)(71-73)(71-85)(72-83)(73-76)(73-81)(74-77)(74-79)(75-76)(75-80)(76-79)(77-80)(78-81)(78-85)(82-86)(83-86)(84-86)(85-86)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 0.52 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HeLa | 5 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| T24 | 6 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HL-7702 | 55 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«apoptosis induction was seen in 38.7% of MPydMP-Ir treated cells (Figure 1).»