Info
| ID | 5085 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | MPytMP-Ir |
| SMILES | Cc1ccc2nc3c4ncccc4c4nc5cc(C)c(C)cc5nc4c3n2c1.Cc1cccnc1-c1[c-]cccc1.Cc1cccnc1-c1[c-]cccc1 |
TUCAN
C47H37IrN7/(1-41)(2-46)(3-48)(4-39)(5-52)(6-39)(7-39)(8-57)(9-40)(10-54)(11-40)(12-58)(13-41)(14-71)(15-41)(16-40)(17-60)(18-72)(19-51)(20-56)(21-38)(22-38)(23-50)(24-73)(25-42)(26-59)(27-45)(28-49)(29-38)(30-61)(31-42)(32-47)(33-55)(34-53)(35-42)(36-74)(37-62)(38-65)(39-63)(40-68)(41-69)(42-70)(43-46)(43-64)(44-55)(44-66)(45-46)(45-57)(47-55)(47-59)(48-58)(48-63)(49-70)(49-81)(50-51)(50-65)(51-84)(52-57)(52-64)(53-59)(53-66)(54-60)(54-68)(56-69)(56-82)(58-71)(60-72)(61-62)(61-67)(62-73)(63-75)(64-75)(65-74)(66-80)(67-76)(67-78)(68-80)(69-70)(71-88)(72-89)(73-90)(74-87)(75-88)(76-77)(76-90)(77-79)(77-91)(78-83)(78-85)(79-83)(79-87)(80-89)(81-82)(81-86)(82-85)(83-86)(84-87)(84-91)(88-92)(89-92)(90-92)(91-92)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 0.005 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| T24 | 1.1 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HeLa | 1.9 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HL-7702 | 63 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«apoptosis induction was seen in 38.7% of MPydMP-Ir treated cells (Figure 1).»