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Complex #5085 — Ir(3) [MPytMP-Ir]

2D Structure

Structure
⬇ MOL V3000

Info

ID5085
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 7}
AbbreviationMPytMP-Ir
SMILESCc1ccc2nc3c4ncccc4c4nc5cc(C)c(C)cc5nc4c3n2c1.Cc1cccnc1-c1[c-]cccc1.Cc1cccnc1-c1[c-]cccc1

TUCAN

C47H37IrN7/(1-41)(2-46)(3-48)(4-39)(5-52)(6-39)(7-39)(8-57)(9-40)(10-54)(11-40)(12-58)(13-41)(14-71)(15-41)(16-40)(17-60)(18-72)(19-51)(20-56)(21-38)(22-38)(23-50)(24-73)(25-42)(26-59)(27-45)(28-49)(29-38)(30-61)(31-42)(32-47)(33-55)(34-53)(35-42)(36-74)(37-62)(38-65)(39-63)(40-68)(41-69)(42-70)(43-46)(43-64)(44-55)(44-66)(45-46)(45-57)(47-55)(47-59)(48-58)(48-63)(49-70)(49-81)(50-51)(50-65)(51-84)(52-57)(52-64)(53-59)(53-66)(54-60)(54-68)(56-69)(56-82)(58-71)(60-72)(61-62)(61-67)(62-73)(63-75)(64-75)(65-74)(66-80)(67-76)(67-78)(68-80)(69-70)(71-88)(72-89)(73-90)(74-87)(75-88)(76-77)(76-90)(77-79)(77-91)(78-83)(78-85)(79-83)(79-87)(80-89)(81-82)(81-86)(82-85)(83-86)(84-87)(84-91)(88-92)(89-92)(90-92)(91-92)

Measurements (4)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
NCI-H4600.005 10.1021/acsmedchemlett.9b00337 2019
T241.1 10.1021/acsmedchemlett.9b00337 2019
HeLa1.9 10.1021/acsmedchemlett.9b00337 2019
HL-770263 10.1021/acsmedchemlett.9b00337 2019

🧬 Cell Death Types (1)

Apoptosis high
«apoptosis induction was seen in 38.7% of MPydMP-Ir treated cells (Figure 1).»