Info
| ID | 5005 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 2 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C34H24IrN4/(1-36)(2-51)(3-41)(4-30)(5-53)(6-42)(7-32)(8-39)(9-31)(10-29)(11-28)(12-45)(13-52)(14-38)(15-54)(16-37)(17-27)(18-33)(19-40)(20-44)(21-43)(22-46)(23-35)(24-34)(25-31)(25-47)(26-35)(26-48)(27-37)(27-55)(28-37)(28-53)(29-38)(29-49)(30-39)(30-49)(31-41)(32-36)(32-41)(33-43)(33-54)(34-43)(34-56)(35-46)(36-47)(38-50)(39-51)(40-44)(40-52)(42-45)(42-48)(44-50)(45-46)(47-55)(48-56)(49-57)(50-58)(51-60)(52-61)(53-59)(54-62)(55-59)(56-62)(57-58)(57-60)(58-61)(59-63)(60-63)(61-63)(62-63)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 16 | — | 10.1021/jm4001665 | 2013 |
| A549 | 16 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
| MCF-7 | 17 | — | 10.1021/jm4001665 | 2013 |
| HeLa | 22 | — | 10.1021/jm4001665 | 2013 |
| A549cisR | 33 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
| LO2 | 74 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The flow cytometry investigations demonstrated that Ir-1 and Ir-3 can arrest the cell cycle in S phase and induce the cell death through apoptosis process.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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