Info
| ID | 50 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 5b |
| SMILES | [Cl-].[O-]c1ccc2ccccc2c1CNCc1ccco1.c1ccccc1 |
TUCAN
C22ClNO2Ru/(1-2)(1-3)(2-9)(3-11)(4-5)(4-7)(5-6)(6-16)(7-17)(8-10)(8-21)(9-12)(10-20)(11-12)(13-14)(13-16)(14-22)(15-17)(15-19)(15-22)(16-17)(18-21)(18-23)(19-23)(20-25)(21-25)(22-24)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 50 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| SH-SY5Y | 59 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| T47D | 1e+02 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| MCF-7 | 1.1e+02 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| MCF-12A | 1.1e+02 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that complex 5a (ID 47) induces apoptosis. However, the MTS assay measures metabolic activity, which is a general cytotoxicity assay, not a specific cell death me...»