Info
| ID | 4977 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 3 |
| Donor atoms | {"N": 4} |
| Abbreviation | 4 |
| SMILES | C[n+]1ccc[c-]c1-c1ccccn1.C[n+]1ccc[c-]c1-c1ccccn1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C46H36IrN6/(1-40)(2-71)(3-69)(4-42)(5-47)(6-39)(7-72)(8-50)(9-44)(10-41)(11-69)(12-69)(13-73)(14-49)(15-48)(16-53)(17-75)(18-74)(19-43)(20-61)(21-76)(22-56)(23-57)(24-54)(25-45)(26-60)(27-51)(28-55)(29-59)(30-58)(31-46)(32-70)(33-62)(34-70)(35-70)(36-52)(37-43)(37-78)(38-61)(38-82)(39-40)(39-48)(40-64)(41-47)(41-48)(42-49)(42-63)(43-50)(44-45)(44-80)(45-46)(46-74)(47-64)(49-67)(50-71)(51-52)(51-81)(52-62)(53-65)(53-72)(54-57)(54-58)(55-57)(55-66)(56-68)(56-73)(58-59)(59-66)(60-61)(60-75)(62-76)(63-65)(63-77)(64-65)(66-68)(67-68)(67-79)(69-83)(70-84)(71-83)(72-85)(73-86)(74-87)(75-84)(76-88)(77-79)(77-85)(78-80)(78-83)(79-86)(80-87)(81-82)(81-88)(82-84)(85-89)(86-89)(87-89)(88-89)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HMLER | 9.1 | — | 10.1002/chem.201803521 | 2018 |
| HMLERshEcad | 14 | — | 10.1002/chem.201803521 | 2018 |
| HepG2 | 34 | — | 10.1002/chem.201803521 | 2018 |
| U2OS | 38 | — | 10.1002/chem.201803521 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Immunoblotting studies showed that HMLER-shEcad cells treated with 3 (2.5, 5, and 10 mm for 72 h) expressed higher levels of cleaved caspase-3 and -7 than control cells, indicative of caspase-dependen...»