Info
| ID | 4976 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 3 |
| Donor atoms | {"N": 4} |
| Abbreviation | 3 |
| SMILES | C[n+]1ccc[c-]c1-c1ccccn1.C[n+]1ccc[c-]c1-c1ccccn1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C34H28IrN6/(1-34)(2-53)(3-52)(4-44)(5-31)(6-33)(7-35)(8-32)(9-49)(10-42)(11-49)(12-41)(13-36)(14-39)(15-45)(16-46)(17-54)(18-56)(19-49)(20-38)(21-51)(22-55)(23-50)(24-50)(25-40)(26-37)(27-43)(28-50)(29-44)(29-58)(30-45)(30-62)(31-37)(31-47)(32-35)(32-60)(33-35)(33-52)(34-39)(34-47)(36-44)(36-53)(37-51)(38-40)(38-41)(39-48)(40-61)(41-56)(42-43)(42-48)(43-55)(45-46)(46-54)(47-57)(48-59)(49-63)(50-64)(51-65)(52-67)(53-63)(54-64)(55-66)(56-68)(57-59)(57-65)(58-60)(58-63)(59-66)(60-67)(61-62)(61-68)(62-64)(65-69)(66-69)(67-69)(68-69)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HMLERshEcad | 5.2 | — | 10.1002/chem.201803521 | 2018 |
| HMLER | 5.4 | — | 10.1002/chem.201803521 | 2018 |
| U2OS | 18 | — | 10.1002/chem.201803521 | 2018 |
| HepG2 | 65 | — | 10.1002/chem.201803521 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Immunoblotting studies showed that HMLER-shEcad cells treated with 3 (2.5, 5, and 10 mm for 72 h) expressed higher levels of cleaved caspase-3 and -7 than control cells, indicative of caspase-dependen...»