Info
| ID | 4975 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 3 |
| Donor atoms | {"N": 4} |
| Abbreviation | 2 |
| SMILES | C[n+]1ccc[c-]c1-c1ccccn1.C[n+]1ccc[c-]c1-c1ccccn1.Cc1ccnc(-c2cc(C)ccn2)c1 |
TUCAN
C34H32IrN6/(1-33)(2-38)(3-53)(4-33)(5-40)(6-56)(7-39)(8-46)(9-41)(10-53)(11-33)(12-49)(13-53)(14-34)(15-34)(16-54)(17-43)(18-34)(19-57)(20-42)(21-47)(22-60)(23-58)(24-37)(25-45)(26-55)(27-44)(28-59)(29-54)(30-48)(31-54)(32-50)(33-51)(34-52)(35-38)(35-62)(36-48)(36-64)(37-51)(37-63)(38-41)(39-42)(39-43)(40-51)(40-55)(41-56)(42-57)(43-61)(44-47)(44-58)(45-52)(45-65)(46-52)(46-59)(47-50)(48-49)(49-60)(50-66)(53-67)(54-68)(55-71)(56-67)(57-69)(58-70)(59-72)(60-68)(61-62)(61-69)(62-67)(63-65)(63-71)(64-66)(64-68)(65-72)(66-70)(69-73)(70-73)(71-73)(72-73)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HMLER | 52 | — | 10.1002/chem.201803521 | 2018 |
| HMLERshEcad | 64 | — | 10.1002/chem.201803521 | 2018 |
| U2OS | — | — | 10.1002/chem.201803521 | 2018 |
| HepG2 | — | — | 10.1002/chem.201803521 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Immunoblotting studies showed that HMLER-shEcad cells treated with 3 (2.5, 5, and 10 mm for 72 h) expressed higher levels of cleaved caspase-3 and -7 than control cells, indicative of caspase-dependen...»