Info
| ID | 4974 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 3 |
| Donor atoms | {"N": 4} |
| Abbreviation | 1 |
| SMILES | C[n+]1ccc[c-]c1-c1ccccn1.C[n+]1ccc[c-]c1-c1ccccn1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C32H28IrN6/(1-34)(2-47)(3-36)(4-50)(5-37)(6-33)(7-39)(8-32)(9-47)(10-38)(11-47)(12-40)(13-48)(14-31)(15-43)(16-35)(17-52)(18-53)(19-46)(20-54)(21-41)(22-42)(23-44)(24-45)(25-49)(26-51)(27-48)(28-48)(29-43)(29-56)(30-46)(30-60)(31-34)(31-37)(32-36)(32-57)(33-36)(33-53)(34-55)(35-43)(35-50)(37-49)(38-41)(38-59)(39-40)(39-44)(40-58)(41-42)(42-51)(44-54)(45-46)(45-52)(47-61)(48-62)(49-63)(50-61)(51-64)(52-62)(53-65)(54-66)(55-59)(55-63)(56-57)(56-61)(57-65)(58-60)(58-66)(59-64)(60-62)(63-67)(64-67)(65-67)(66-67)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| U2OS | — | — | 10.1002/chem.201803521 | 2018 |
| HepG2 | — | — | 10.1002/chem.201803521 | 2018 |
| HMLER | — | — | 10.1002/chem.201803521 | 2018 |
| HMLERshEcad | — | — | 10.1002/chem.201803521 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Immunoblotting studies showed that HMLER-shEcad cells treated with 3 (2.5, 5, and 10 mm for 72 h) expressed higher levels of cleaved caspase-3 and -7 than control cells, indicative of caspase-dependen...»