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Complex #4971 — Ir(3) [Ir2]

2D Structure

Structure
⬇ MOL V3000

Info

ID4971
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 5}
AbbreviationIr2
SMILESO=C(CCCc1ccccc1)Nc1ccnc(-c2ccccn2)c1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1

TUCAN

C42H35IrN5O/(1-69)(2-46)(3-47)(4-70)(5-68)(6-45)(7-48)(8-39)(9-56)(10-38)(11-49)(12-53)(13-40)(14-54)(15-62)(16-62)(17-64)(18-64)(19-63)(20-63)(21-43)(22-59)(23-50)(24-42)(25-44)(26-51)(27-57)(28-41)(29-61)(30-71)(31-60)(32-55)(33-58)(34-52)(35-78)(36-38)(36-65)(37-53)(37-67)(38-46)(39-40)(39-72)(40-47)(41-54)(41-73)(42-71)(42-74)(43-59)(43-66)(44-60)(44-75)(45-74)(45-76)(46-48)(47-69)(48-49)(49-65)(50-59)(50-61)(51-60)(51-68)(52-61)(52-66)(53-55)(54-56)(55-57)(56-70)(57-58)(58-67)(62-63)(62-66)(63-64)(64-77)(65-72)(67-73)(68-80)(69-79)(70-81)(71-82)(72-79)(73-81)(74-78)(75-76)(75-80)(76-82)(77-78)(77-83)(79-84)(80-84)(81-84)(82-84)

Measurements (15)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HLF2.5 10.1002/ange.202013987 2021
BEAS-2B2.8 10.1002/ange.202013987 2021
Lewis lung carcinoma3 10.1002/ange.202013987 2021
A5493.6 10.1002/ange.202013987 2021
A549cisR3.9 10.1002/ange.202013987 2021
MDA-MB-2314 10.1002/ange.202013987 2021
CT-265.7 10.1002/ange.202013987 2021
MDA-MB-2316.71 10.1039/d2sc06675k 2023
A3756.85 10.1039/d2sc06675k 2023
SW6208.22.2 10.1039/d2sc06675k 2023
4T18.34 10.1039/d2sc06675k 2023
A54991.5 10.1039/d2sc06675k 2023
B16-F109.72.9 10.1039/d2sc06675k 2023
LLC151.4 10.1039/d2sc06675k 2023
CT-261517 10.1039/d2sc06675k 2023

🧬 Cell Death Types (2)

Ferroptosis high
«The combination of these findings indicated that the treatment with Ir-pbt-Bpa and exposure to light irradiation likely causes cell death by ferroptosis.»
Immunogenic Cell Death high
«The combination of these findings indicates that Ir-pbt-Bpa can trigger ICD upon light irradiation.»