Info
| ID | 4969 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 5 |
| SMILES | FC(F)(F)c1ccc(Cn2c(-c3[c-]cccc3)nc3ccccc32)cc1.FC(F)(F)c1ccc(Cn2c(-c3[c-]cccc3)nc3ccccc32)cc1.O=c1[nH]c2cc3nc4c5cccnc5c5ncccc5c4nc3cc2[nH]1 |
TUCAN
C61H38F6IrN10O/(1-43)(2-41)(3-65)(4-66)(5-49)(6-46)(7-67)(8-57)(9-44)(10-64)(11-58)(12-54)(13-80)(14-79)(15-42)(16-50)(17-48)(18-60)(19-63)(20-47)(21-62)(22-55)(23-52)(24-45)(25-81)(26-51)(27-61)(28-53)(29-68)(30-81)(31-69)(32-82)(33-70)(34-56)(35-82)(36-59)(37-102)(38-103)(39-50)(39-71)(40-56)(40-76)(41-54)(41-78)(42-48)(42-65)(43-86)(43-88)(44-64)(44-71)(45-63)(45-79)(46-57)(46-74)(47-58)(47-74)(48-49)(49-85)(50-66)(51-68)(51-76)(52-60)(52-77)(53-61)(53-77)(54-80)(55-62)(55-87)(56-70)(57-72)(58-72)(59-62)(59-69)(60-73)(61-73)(63-75)(64-66)(65-90)(67-91)(67-93)(68-70)(69-94)(71-95)(72-98)(73-99)(74-81)(75-84)(75-89)(76-96)(77-82)(78-83)(78-92)(79-109)(80-100)(81-104)(82-105)(83-89)(83-100)(84-92)(84-108)(85-90)(85-106)(86-91)(86-102)(87-94)(87-107)(88-93)(88-101)(89-109)(90-104)(91-103)(92-101)(93-108)(94-105)(95-104)(95-106)(96-105)(96-107)(97-102)(97-103)(97-110)(98-111)(98-112)(98-113)(99-114)(99-115)(99-116)(106-117)(107-117)(108-117)(109-117)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780cisR | 3.4 | — | 10.1002/chem.201705362 | 2018 |
| A2780 | 4.7 | — | 10.1002/chem.201705362 | 2018 |
| MCF-7 | 11 | — | 10.1002/chem.201705362 | 2018 |
| HeLa | 23 | — | 10.1002/chem.201705362 | 2018 |
| MCF-10A | 41 | — | 10.1002/chem.201705362 | 2018 |
🧬 Cell Death Types (2)
Apoptosis
medium
«Presumably, [1a]Cl and [3a]Cl induce death on cancer cells under irradiation through apoptosis triggered by a multimodal mechanism of action, which likely involves damage over mitochondrial DNA and mi...»
Immunogenic Cell Death
low
«No explicit evidence found.»