Info
| ID | 4966 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 1 |
| SMILES | FC(F)(F)c1ccc(Cn2c(-c3[c-]cccc3)nc3ccccc32)cc1.FC(F)(F)c1ccc(Cn2c(-c3[c-]cccc3)nc3ccccc32)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C66H44F6IrN6/(1-48)(2-54)(3-47)(4-97)(5-56)(6-49)(7-98)(8-53)(9-63)(10-61)(11-58)(12-59)(13-99)(14-67)(15-62)(16-60)(17-99)(18-68)(19-51)(20-57)(21-70)(22-52)(23-100)(24-71)(25-75)(26-50)(27-69)(28-100)(29-80)(30-55)(31-77)(32-74)(33-65)(34-64)(35-79)(36-76)(37-78)(38-73)(39-82)(40-72)(41-84)(42-81)(43-66)(44-83)(45-64)(45-92)(46-73)(46-93)(47-48)(47-88)(48-53)(49-58)(49-90)(50-63)(50-92)(51-61)(51-88)(52-59)(52-60)(53-61)(54-89)(54-97)(55-63)(55-64)(56-59)(56-102)(57-70)(57-91)(58-87)(60-101)(62-65)(62-74)(65-80)(66-78)(66-84)(67-77)(67-87)(68-94)(68-98)(69-70)(69-75)(71-72)(71-85)(72-86)(73-78)(74-105)(75-76)(76-91)(77-90)(79-82)(79-96)(80-106)(81-83)(81-96)(82-95)(83-95)(84-93)(85-89)(85-103)(86-94)(86-104)(87-109)(88-89)(90-99)(91-94)(92-107)(93-108)(95-100)(96-110)(97-113)(98-115)(99-111)(100-112)(101-102)(101-114)(102-111)(103-104)(103-113)(104-115)(105-106)(105-112)(106-116)(107-111)(107-114)(108-112)(108-116)(109-117)(109-118)(109-119)(110-120)(110-121)(110-122)(113-123)(114-123)(115-123)(116-123)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780cisR | 0.38 | — | 10.1002/chem.201705362 | 2018 |
| A2780 | 0.63 | — | 10.1002/chem.201705362 | 2018 |
| MCF-7 | 0.7 | — | 10.1002/chem.201705362 | 2018 |
| HeLa | 1.8 | — | 10.1002/chem.201705362 | 2018 |
| MCF-10A | 2.6 | — | 10.1002/chem.201705362 | 2018 |
🧬 Cell Death Types (2)
Apoptosis
medium
«Presumably, [1a]Cl and [3a]Cl induce death on cancer cells under irradiation through apoptosis triggered by a multimodal mechanism of action, which likely involves damage over mitochondrial DNA and mi...»
Immunogenic Cell Death
low
«No explicit evidence found.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
Loading source metadata…
The generated SVG will appear here. The legacy ligand image above stays visible for side-by-side review.