Info
| ID | 4965 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ferrilidium |
| SMILES | Oc1ccc(Nc2ccnc(-c3ccccn3)c2)cc1O.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C38H29IrN5O2/(1-56)(2-48)(3-41)(4-39)(5-32)(6-51)(7-34)(8-40)(9-49)(10-33)(11-43)(12-38)(13-58)(14-46)(15-47)(16-59)(17-36)(18-44)(19-42)(20-45)(21-35)(22-37)(23-57)(24-52)(25-50)(26-53)(27-68)(28-74)(29-73)(30-48)(30-54)(31-52)(31-55)(32-34)(32-54)(33-41)(33-56)(34-39)(35-38)(35-59)(36-63)(36-66)(37-61)(37-64)(38-47)(39-48)(40-41)(40-60)(42-50)(42-55)(43-51)(43-57)(44-50)(44-52)(45-53)(45-63)(46-58)(46-64)(47-65)(49-51)(49-62)(53-67)(54-60)(55-62)(56-69)(57-70)(58-72)(59-71)(60-69)(61-65)(61-72)(62-70)(63-68)(64-68)(65-71)(66-67)(66-73)(67-74)(69-75)(70-75)(71-75)(72-75)(74-75)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| AGS | 9.2 | — | 10.1002/ange.201915828 | 2020 |
| MKN-28 | 11 | — | 10.1002/ange.201915828 | 2020 |
| HepG2 | 12 | — | 10.1002/ange.201915828 | 2020 |
| A549 | 68 | — | 10.1002/ange.201915828 | 2020 |
| SW620 | 85 | — | 10.1002/ange.201915828 | 2020 |
| LO2 | — | — | 10.1002/ange.201915828 | 2020 |
| GES-1 | — | — | 10.1002/ange.201915828 | 2020 |
| MCF-10A | — | — | 10.1002/ange.201915828 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
low
«Together, these effects lead to the death of the gastric cancer cells and shrinking of the tumors, as demonstrated by experiments on cell lines and mice.»