Info
| ID | 4953 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.[Cl-].c1ccc(-c2ccccn2)nc1 |
TUCAN
C20H23IrN2/(1-30)(2-31)(3-24)(4-24)(5-24)(6-25)(7-25)(8-25)(9-26)(10-33)(11-32)(12-29)(13-40)(14-41)(15-34)(16-26)(17-26)(18-27)(19-27)(20-27)(21-28)(22-28)(23-28)(24-35)(25-36)(26-37)(27-38)(28-39)(29-30)(29-42)(30-31)(31-40)(32-33)(32-34)(33-41)(34-43)(35-36)(35-37)(36-38)(37-39)(38-39)(40-44)(41-45)(42-43)(42-44)(43-45)(44-46)(45-46)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | — | — | 10.1002/cbic.201900268 | 2019 |
| A2780 | — | — | 10.1021/jm2000932 | 2011 |
| A549 | — | — | 10.1039/c9qi01161g | 2020 |
| HeLa | — | — | 10.1039/c9qi01161g | 2020 |
| BEAS-2B | — | — | 10.1039/c9qi01161g | 2020 |
| A2780 | — | — | 10.1021/ic200607j | 2011 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes induce a dose-dependent increase in the percentage of apoptotic cells after 24 h of treatment. The percentage of early apoptosis and late apoptosis cells increased from 1.7% and 9.8% to 8.1%...»