Info
| ID | 4950 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 2 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.[Cl-].c1ccc(C(=C(c2ccccc2)c2ccc(-c3ccnc(-c4cc(-c5ccc(C(=C(c6ccccc6)c6ccccc6)c6ccccc6)cc5)ccn4)c3)cc2)c2ccccc2)cc1 |
TUCAN
C72H59IrN2/(1-128)(2-85)(3-73)(4-75)(5-69)(6-60)(7-60)(8-60)(9-61)(10-61)(11-76)(12-66)(13-87)(14-67)(15-70)(16-78)(17-82)(18-96)(19-71)(20-98)(21-65)(22-81)(23-92)(24-68)(25-84)(26-72)(27-86)(28-74)(29-88)(30-79)(31-83)(32-90)(33-80)(34-99)(35-101)(36-100)(37-77)(38-91)(39-94)(40-89)(41-105)(42-95)(43-102)(44-104)(45-93)(46-106)(47-97)(48-129)(49-103)(50-61)(51-62)(52-62)(53-62)(54-63)(55-63)(56-63)(57-64)(58-64)(59-64)(60-108)(61-109)(62-110)(63-111)(64-112)(65-66)(65-76)(66-107)(67-68)(67-107)(68-76)(69-73)(69-116)(70-75)(70-80)(71-118)(71-130)(72-79)(72-81)(73-121)(74-79)(74-84)(75-113)(77-86)(77-100)(78-80)(78-82)(81-114)(82-113)(83-87)(83-121)(84-114)(85-118)(85-128)(86-115)(87-116)(88-89)(88-115)(89-100)(90-119)(90-129)(91-96)(91-117)(92-99)(92-126)(93-94)(93-104)(94-125)(95-98)(95-117)(96-97)(97-98)(99-127)(101-119)(101-131)(102-105)(102-127)(103-104)(103-106)(105-126)(106-125)(107-123)(108-109)(108-110)(109-111)(110-112)(111-112)(113-120)(114-123)(115-124)(116-118)(117-122)(119-126)(120-121)(120-123)(122-124)(122-127)(124-125)(128-132)(129-133)(130-131)(130-132)(131-133)(132-134)(133-134)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 17 | — | 10.1002/cbic.201900268 | 2019 |
| BEAS-2B | 21 | — | 10.1002/cbic.201900268 | 2019 |
| 16HBE | 35 | — | 10.1002/cbic.201900268 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes induce a dose-dependent increase in the percentage of apoptotic cells after 24 h of treatment. The percentage of early apoptosis and late apoptosis cells increased from 1.7% and 9.8% to 8.1%...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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