Info
| ID | 4949 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 1 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.[Cl-].c1ccc(C(=C(c2ccccc2)c2ccc(-c3ccnc(-c4ccccn4)c3)cc2)c2ccccc2)cc1 |
TUCAN
C46H41IrN2/(1-54)(2-49)(3-58)(4-53)(5-85)(6-42)(7-42)(8-42)(9-43)(10-43)(11-47)(12-52)(13-51)(14-84)(15-48)(16-55)(17-60)(18-62)(19-66)(20-64)(21-69)(22-50)(23-59)(24-56)(25-61)(26-63)(27-57)(28-70)(29-67)(30-68)(31-65)(32-43)(33-44)(34-44)(35-44)(36-45)(37-45)(38-45)(39-46)(40-46)(41-46)(42-72)(43-73)(44-74)(45-75)(46-76)(47-71)(47-84)(48-53)(48-87)(49-71)(49-86)(50-51)(50-60)(51-77)(52-54)(52-82)(53-58)(54-81)(55-56)(55-77)(56-60)(57-59)(57-69)(58-85)(59-78)(61-64)(61-67)(62-64)(62-83)(63-67)(63-83)(65-66)(65-81)(66-82)(68-69)(68-70)(70-78)(71-81)(72-73)(72-74)(73-75)(74-76)(75-76)(77-80)(78-80)(79-80)(79-82)(79-83)(84-88)(85-89)(86-87)(86-88)(87-89)(88-90)(89-90)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 3.6 | — | 10.1002/cbic.201900268 | 2019 |
| BEAS-2B | 6.3 | — | 10.1002/cbic.201900268 | 2019 |
| 16HBE | 6.6 | — | 10.1002/cbic.201900268 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes induce a dose-dependent increase in the percentage of apoptotic cells after 24 h of treatment. The percentage of early apoptosis and late apoptosis cells increased from 1.7% and 9.8% to 8.1%...»