Info
| ID | 4923 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | 1 |
| SMILES | CN1CCN(c2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)CC1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C46H38IrN8/(1-46)(2-42)(3-54)(4-60)(5-69)(6-47)(7-74)(8-70)(9-45)(10-41)(11-43)(12-74)(13-44)(14-48)(15-68)(16-68)(17-73)(18-73)(19-57)(20-76)(21-76)(22-68)(23-50)(24-72)(25-55)(26-75)(27-61)(28-53)(29-52)(30-56)(31-51)(32-71)(33-49)(34-75)(35-62)(36-59)(37-58)(38-86)(39-41)(39-63)(40-44)(40-64)(41-47)(42-46)(42-47)(43-52)(43-77)(44-48)(45-52)(45-69)(46-63)(48-60)(49-55)(49-65)(50-51)(50-66)(51-72)(53-59)(53-70)(54-60)(54-64)(55-71)(56-57)(56-67)(57-83)(58-59)(58-78)(61-62)(61-83)(62-67)(63-77)(64-78)(65-79)(65-82)(66-80)(66-81)(67-84)(68-87)(69-89)(70-91)(71-85)(72-92)(73-74)(73-88)(74-87)(75-76)(75-88)(76-87)(77-89)(78-91)(79-80)(79-86)(80-90)(81-82)(81-92)(82-85)(83-88)(84-86)(84-90)(89-93)(90-93)(91-93)(92-93)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 5.4 | — | 10.1016/j.jinorgbio.2020.11121... | 2020 |
| SGC-7901 | 10 | — | 10.1016/j.jinorgbio.2020.11121... | 2020 |
| NIH-3T3 | 11 | — | 10.1016/j.jinorgbio.2020.11121... | 2020 |
| HeLa | 25 | — | 10.1016/j.jinorgbio.2020.11121... | 2020 |
| BEL-7402 | 25 | — | 10.1016/j.jinorgbio.2020.11121... | 2020 |
| A375 | — | 4.1 | 10.1002/adhm.202301227 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«They target mitochondria in human melanoma tumor cells and trigger apoptosis related to mitochondrial dysfunction upon irradiation.»