Info
| ID | 4903 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 5 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C32H24IrN4/(1-35)(2-36)(3-38)(4-49)(5-29)(6-44)(7-45)(8-27)(9-42)(10-30)(11-28)(12-40)(13-32)(14-33)(15-34)(16-37)(17-41)(18-31)(19-50)(20-52)(21-39)(22-51)(23-43)(24-46)(25-30)(25-47)(26-33)(26-48)(27-35)(27-54)(28-35)(28-49)(29-36)(29-50)(30-38)(31-34)(31-38)(32-44)(32-55)(33-45)(34-47)(36-37)(37-53)(39-46)(39-48)(40-41)(40-42)(41-56)(42-52)(43-44)(43-51)(45-46)(47-54)(48-55)(49-57)(50-58)(51-59)(52-60)(53-56)(53-58)(54-57)(55-59)(56-60)(57-61)(58-61)(59-61)(60-61)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| LO2 | 1.1 | — | 10.1002/ange.202015671 | 2021 |
| HEK293T | 8.4 | — | 10.1002/ange.202015671 | 2021 |
| NP69 | 15 | — | 10.1002/ange.202015671 | 2021 |
| A549 | 22 | — | 10.1021/jm4001665 | 2013 |
| MCF-7 | 23 | — | 10.1021/jm4001665 | 2013 |
| HeLa | 27 | — | 10.1021/jm4001665 | 2013 |
| A549 | 40 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| A549 | 40 | — | 10.1002/cbic.201900268 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«In addition, about 43.5% of A549 cells treated with complex 3 were undergoing apoptosis, 41.9% of which were in late apoptosis.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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