Info
| ID | 483 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 7 |
| SMILES | COc1ccc(/C=C/c2ccnc(-c3cc(/C=C/c4ccc(OC)cc4)ccn3)c2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C48H40N6O2Ru/(1-73)(2-57)(3-43)(4-49)(5-85)(6-58)(7-46)(8-59)(9-85)(10-61)(11-41)(12-54)(13-74)(14-50)(15-42)(16-85)(17-55)(18-52)(19-51)(20-86)(21-63)(22-62)(23-86)(24-86)(25-64)(26-56)(27-53)(28-67)(29-75)(30-65)(31-66)(32-76)(33-60)(34-68)(35-77)(36-78)(37-47)(38-44)(39-48)(40-45)(41-43)(41-73)(42-47)(42-74)(43-58)(44-46)(44-75)(45-48)(45-76)(46-59)(47-65)(48-66)(49-57)(49-69)(50-61)(50-69)(51-52)(51-69)(52-70)(53-56)(53-71)(54-70)(54-77)(55-71)(55-78)(56-72)(57-87)(58-79)(59-80)(60-70)(60-83)(61-87)(62-63)(62-88)(63-72)(64-67)(64-88)(65-81)(66-82)(67-72)(68-71)(68-84)(73-89)(74-90)(75-91)(76-92)(77-93)(78-94)(79-80)(79-89)(80-91)(81-82)(81-90)(82-92)(83-84)(83-93)(84-94)(85-95)(86-96)(87-95)(88-96)(89-97)(90-97)(91-97)(92-97)(93-97)(94-97)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPE-1 | — | 3.1 | 10.1038/s41467-020-16993-0 | 2020 |
| RPE-1 | — | 8.4 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 1.2 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 1.5 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 0.7 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 0.9 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 10 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 14 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 0.56 | 10.1039/d1dt02083h | 2021 |
| RPE-1 | — | 1.6 | 10.1039/d1dt02083h | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»
Paraptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»