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Complex #483 — Ru(2) [7]

2D Structure

Structure
⬇ MOL V3000

Info

ID483
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 6}
Abbreviation7
SMILESCOc1ccc(/C=C/c2ccnc(-c3cc(/C=C/c4ccc(OC)cc4)ccn3)c2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1

TUCAN

C48H40N6O2Ru/(1-73)(2-57)(3-43)(4-49)(5-85)(6-58)(7-46)(8-59)(9-85)(10-61)(11-41)(12-54)(13-74)(14-50)(15-42)(16-85)(17-55)(18-52)(19-51)(20-86)(21-63)(22-62)(23-86)(24-86)(25-64)(26-56)(27-53)(28-67)(29-75)(30-65)(31-66)(32-76)(33-60)(34-68)(35-77)(36-78)(37-47)(38-44)(39-48)(40-45)(41-43)(41-73)(42-47)(42-74)(43-58)(44-46)(44-75)(45-48)(45-76)(46-59)(47-65)(48-66)(49-57)(49-69)(50-61)(50-69)(51-52)(51-69)(52-70)(53-56)(53-71)(54-70)(54-77)(55-71)(55-78)(56-72)(57-87)(58-79)(59-80)(60-70)(60-83)(61-87)(62-63)(62-88)(63-72)(64-67)(64-88)(65-81)(66-82)(67-72)(68-71)(68-84)(73-89)(74-90)(75-91)(76-92)(77-93)(78-94)(79-80)(79-89)(80-91)(81-82)(81-90)(82-92)(83-84)(83-93)(84-94)(85-95)(86-96)(87-95)(88-96)(89-97)(90-97)(91-97)(92-97)(93-97)(94-97)

Measurements (10)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
RPE-13.1 10.1038/s41467-020-16993-0 2020
RPE-18.4 10.1038/s41467-020-16993-0 2020
HeLa1.2 10.1038/s41467-020-16993-0 2020
HeLa1.5 10.1038/s41467-020-16993-0 2020
CT-260.7 10.1038/s41467-020-16993-0 2020
CT-260.9 10.1038/s41467-020-16993-0 2020
U37310 10.1038/s41467-020-16993-0 2020
U37314 10.1038/s41467-020-16993-0 2020
HeLa0.56 10.1039/d1dt02083h 2021
RPE-11.6 10.1039/d1dt02083h 2021

🧬 Cell Death Types (2)

Apoptosis high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»
Paraptosis high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»