Info
| ID | 482 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 6 |
| SMILES | CN(C)c1ccc(/C=C/c2ccnc(-c3cc(/C=C/c4ccc(N(C)C)cc4)ccn3)c2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C50H46N8Ru/(1-50)(2-49)(3-68)(4-79)(5-52)(6-79)(7-67)(8-53)(9-83)(10-70)(11-79)(12-80)(13-56)(14-69)(15-47)(16-48)(17-80)(18-57)(19-84)(20-80)(21-81)(22-81)(23-81)(24-82)(25-82)(26-82)(27-60)(28-86)(29-59)(30-55)(31-54)(32-87)(33-74)(34-73)(35-66)(36-62)(37-65)(38-63)(39-71)(40-58)(41-85)(42-51)(43-72)(44-88)(45-64)(46-61)(47-49)(47-89)(48-68)(48-90)(49-50)(50-83)(51-70)(51-91)(52-53)(52-93)(53-75)(54-62)(54-75)(55-56)(55-75)(56-93)(57-58)(57-96)(58-76)(59-77)(59-92)(60-77)(60-86)(61-64)(61-76)(62-77)(63-66)(63-78)(64-96)(65-78)(65-87)(66-76)(67-70)(67-84)(68-69)(69-85)(71-78)(71-95)(72-74)(72-94)(73-74)(73-88)(79-97)(80-97)(81-98)(82-98)(83-99)(84-100)(85-101)(86-102)(87-104)(88-103)(89-90)(89-99)(90-101)(91-94)(91-100)(92-95)(92-102)(93-97)(94-103)(95-104)(96-98)(99-105)(100-105)(101-105)(102-105)(103-105)(104-105)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPE-1 | — | 7.3 | 10.1038/s41467-020-16993-0 | 2020 |
| RPE-1 | — | 8.1 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 5.3 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 5.8 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 2.4 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 3.1 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 8.3 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 11 | 10.1038/s41467-020-16993-0 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»
Paraptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»