Info
| ID | 481 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 5 |
| SMILES | COc1ccc(/C=C/c2ccnc(-c3cc(/C=C/c4ccc(OC)cc4)ccn3)c2)cc1.COc1ccc(/C=C/c2ccnc(-c3cc(/C=C/c4ccc(OC)cc4)ccn3)c2)cc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C66H56N6O4Ru/(1-103)(2-58)(3-63)(4-74)(5-59)(6-57)(7-62)(8-104)(9-76)(10-108)(11-115)(12-68)(13-79)(14-80)(15-77)(16-88)(17-64)(18-66)(19-73)(20-82)(21-105)(22-67)(23-89)(24-115)(25-65)(26-90)(27-61)(28-115)(29-81)(30-71)(31-116)(32-72)(33-92)(34-84)(35-83)(36-75)(37-60)(38-86)(39-78)(40-116)(41-91)(42-116)(43-117)(44-106)(45-117)(46-117)(47-94)(48-93)(49-118)(50-69)(51-70)(52-107)(53-118)(54-118)(55-85)(56-87)(57-60)(57-109)(58-65)(58-95)(59-96)(59-104)(60-61)(61-103)(62-74)(62-95)(63-96)(63-111)(64-97)(64-112)(65-96)(66-71)(66-98)(67-97)(67-105)(68-76)(68-95)(69-99)(69-113)(70-100)(70-114)(71-97)(72-78)(72-108)(73-75)(73-101)(74-119)(75-99)(76-119)(77-80)(77-120)(78-79)(79-110)(80-98)(81-99)(81-106)(82-88)(82-120)(83-85)(83-102)(84-89)(84-121)(85-100)(86-90)(86-121)(87-100)(87-107)(88-98)(89-101)(90-101)(91-92)(91-122)(92-102)(93-94)(93-102)(94-122)(103-123)(104-124)(105-125)(106-126)(107-127)(108-128)(109-110)(109-123)(110-128)(111-113)(111-124)(112-114)(112-125)(113-126)(114-127)(115-129)(116-130)(117-131)(118-132)(119-129)(120-130)(121-131)(122-132)(123-133)(124-133)(125-133)(126-133)(127-133)(128-133)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPE-1 | — | 10 | 10.1038/s41467-020-16993-0 | 2020 |
| RPE-1 | — | 13 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 6.4 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 7.9 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 5.1 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 6.2 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 15 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 18 | 10.1038/s41467-020-16993-0 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»
Paraptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»