Info
| ID | 480 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4 |
| SMILES | CN(C)c1ccc(/C=C/c2ccnc(-c3cc(/C=C/c4ccc(N(C)C)cc4)ccn3)c2)cc1.CN(C)c1ccc(/C=C/c2ccnc(-c3cc(/C=C/c4ccc(N(C)C)cc4)ccn3)c2)cc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C70H68N10Ru/(1-69)(2-85)(3-115)(4-115)(5-124)(6-70)(7-72)(8-123)(9-76)(10-75)(11-84)(12-90)(13-115)(14-116)(15-74)(16-125)(17-77)(18-116)(19-78)(20-126)(21-88)(22-80)(23-82)(24-116)(25-117)(26-117)(27-117)(28-118)(29-118)(30-118)(31-98)(32-119)(33-119)(34-119)(35-71)(36-83)(37-127)(38-89)(39-120)(40-79)(41-91)(42-120)(43-100)(44-86)(45-93)(46-120)(47-95)(48-96)(49-81)(50-87)(51-128)(52-94)(53-121)(54-92)(55-106)(56-97)(57-103)(58-121)(59-121)(60-122)(61-122)(62-122)(63-101)(64-73)(65-102)(66-99)(67-105)(68-104)(69-70)(69-131)(70-108)(71-75)(71-107)(72-74)(72-131)(73-85)(73-129)(74-108)(75-108)(76-77)(76-132)(77-111)(78-107)(78-130)(79-91)(79-109)(80-82)(80-111)(81-96)(81-110)(82-132)(83-109)(83-133)(84-107)(84-124)(85-90)(86-110)(86-134)(87-112)(87-135)(88-109)(88-126)(89-93)(89-102)(90-123)(91-111)(92-106)(92-112)(93-125)(94-110)(94-127)(95-98)(95-113)(96-113)(97-100)(97-113)(98-136)(99-112)(99-128)(100-136)(101-103)(101-114)(102-137)(103-138)(104-105)(104-138)(105-114)(106-114)(115-139)(116-139)(117-140)(118-140)(119-141)(120-141)(121-142)(122-142)(123-143)(124-144)(125-146)(126-145)(127-147)(128-148)(129-137)(129-143)(130-133)(130-144)(131-139)(132-140)(133-145)(134-135)(134-147)(135-148)(136-141)(137-146)(138-142)(143-149)(144-149)(145-149)(146-149)(147-149)(148-149)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPE-1 | — | 11 | 10.1038/s41467-020-16993-0 | 2020 |
| RPE-1 | — | 15 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 8.5 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 11 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 7.3 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 9.6 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 14 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 19 | 10.1038/s41467-020-16993-0 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»
Paraptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»