Info
| ID | 48 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 2b |
| SMILES | [Cl-].[O-]c1ccc2ccccc2c1C=NCc1ccco1.c1ccccc1 |
TUCAN
C22H18NO2Ru/(1-19)(2-20)(3-38)(4-37)(5-37)(6-25)(7-36)(8-29)(9-21)(10-22)(11-28)(12-23)(13-24)(14-27)(15-26)(16-32)(17-31)(18-30)(19-20)(19-21)(20-22)(21-23)(22-24)(23-24)(25-27)(25-33)(26-27)(26-30)(28-29)(28-38)(29-39)(30-35)(31-32)(31-40)(32-35)(33-34)(33-35)(34-36)(34-40)(36-41)(37-39)(37-41)(38-43)(39-43)(40-42)(41-44)(43-44)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-12A | 1e+02 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| T47D | 1.1e+02 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| A2780 | 1.4e+02 | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| SH-SY5Y | — | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
| MCF-7 | — | — | 10.1021/acs.inorgchem.8b00346 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that complex 5a (ID 47) induces apoptosis. However, the MTS assay measures metabolic activity, which is a general cytotoxicity assay, not a specific cell death me...»