Info
| ID | 4798 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | RuOA2 |
| SMILES | CCCCCCCC/C=C\CCCCCCCC(=O)NCCNC(=O)c1ccnc(-c2cc(C(=O)NCCNC(=O)CCCCCCC/C=C\CCCCCCCC)ccn2)c1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C72H100N10O4Ru/(1-116)(2-134)(3-142)(4-125)(5-101)(6-140)(7-123)(8-113)(9-159)(10-143)(11-124)(12-129)(13-118)(14-115)(15-104)(16-103)(17-105)(18-153)(19-138)(20-106)(21-132)(22-154)(23-110)(24-108)(25-107)(26-155)(27-101)(28-129)(29-124)(30-143)(31-159)(32-160)(33-114)(34-123)(35-140)(36-101)(37-125)(38-142)(39-134)(40-138)(41-111)(42-132)(43-145)(44-102)(45-141)(46-144)(47-128)(48-127)(49-148)(50-149)(51-137)(52-119)(53-162)(54-139)(55-150)(56-126)(57-160)(58-131)(59-161)(60-126)(61-139)(62-150)(63-131)(64-162)(65-120)(66-148)(67-149)(68-128)(69-127)(70-141)(71-144)(72-145)(73-102)(74-102)(75-130)(76-147)(77-161)(78-130)(79-157)(80-158)(81-136)(82-147)(83-112)(84-109)(85-135)(86-136)(87-146)(88-117)(89-133)(90-122)(91-121)(92-133)(93-156)(94-146)(95-137)(96-135)(97-173)(98-174)(99-175)(100-176)(101-129)(102-145)(103-104)(103-105)(104-153)(105-163)(106-107)(106-164)(107-108)(108-154)(109-110)(109-112)(110-165)(111-121)(111-166)(112-157)(113-114)(113-143)(114-134)(115-151)(115-167)(116-151)(116-155)(117-152)(117-168)(118-152)(118-156)(119-120)(119-137)(120-148)(121-122)(122-158)(123-124)(123-142)(124-125)(125-140)(126-139)(126-170)(127-128)(127-141)(128-149)(129-140)(130-131)(130-132)(131-138)(132-134)(133-136)(133-150)(135-136)(135-137)(138-139)(141-144)(142-143)(144-145)(146-147)(146-172)(147-150)(148-149)(151-169)(152-171)(153-177)(154-178)(155-179)(156-180)(157-181)(158-182)(159-160)(159-173)(160-174)(161-162)(161-176)(162-175)(163-166)(163-177)(164-165)(164-178)(165-181)(166-182)(167-168)(167-179)(168-180)(169-174)(169-184)(170-173)(170-183)(171-176)(171-185)(172-175)(172-186)(177-187)(178-187)(179-187)(180-187)(181-187)(182-187)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| CT-26 | 0.26 | — | 10.1021/acsnano.4c17344 | 2025 |
| HCT-116 | 0.33 | — | 10.1021/acsnano.4c17344 | 2025 |
| NCI-H1975 | 3.7 | — | 10.1021/acsnano.4c17344 | 2025 |
| MCF-7 | 4.1 | — | 10.1021/acsnano.4c17344 | 2025 |
| HeLa | 10 | — | 10.1021/acsnano.4c17344 | 2025 |
| HepG2 | 16 | — | 10.1021/acsnano.4c17344 | 2025 |
| PANC-1 | 17 | — | 10.1021/acsnano.4c17344 | 2025 |
| A549 | 17 | — | 10.1021/acsnano.4c17344 | 2025 |
| HEK293T | 20 | — | 10.1021/acsnano.4c17344 | 2025 |
🧬 Cell Death Types (2)
Autophagy
high
«RuOA2 induces ferritinophagy... the autophagy inhibitor CQ... significantly increased cell viability»
Ferroptosis
high
«RuOA2 ruthenosomes effectively induce ferritinophagy-mediated tumor cell death»