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Complex #4798 — Ru(2) [RuOA2]

2D Structure

Structure
⬇ MOL V3000

Info

ID4798
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 6}
AbbreviationRuOA2
SMILESCCCCCCCC/C=C\CCCCCCCC(=O)NCCNC(=O)c1ccnc(-c2cc(C(=O)NCCNC(=O)CCCCCCC/C=C\CCCCCCCC)ccn2)c1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1

TUCAN

C72H100N10O4Ru/(1-116)(2-134)(3-142)(4-125)(5-101)(6-140)(7-123)(8-113)(9-159)(10-143)(11-124)(12-129)(13-118)(14-115)(15-104)(16-103)(17-105)(18-153)(19-138)(20-106)(21-132)(22-154)(23-110)(24-108)(25-107)(26-155)(27-101)(28-129)(29-124)(30-143)(31-159)(32-160)(33-114)(34-123)(35-140)(36-101)(37-125)(38-142)(39-134)(40-138)(41-111)(42-132)(43-145)(44-102)(45-141)(46-144)(47-128)(48-127)(49-148)(50-149)(51-137)(52-119)(53-162)(54-139)(55-150)(56-126)(57-160)(58-131)(59-161)(60-126)(61-139)(62-150)(63-131)(64-162)(65-120)(66-148)(67-149)(68-128)(69-127)(70-141)(71-144)(72-145)(73-102)(74-102)(75-130)(76-147)(77-161)(78-130)(79-157)(80-158)(81-136)(82-147)(83-112)(84-109)(85-135)(86-136)(87-146)(88-117)(89-133)(90-122)(91-121)(92-133)(93-156)(94-146)(95-137)(96-135)(97-173)(98-174)(99-175)(100-176)(101-129)(102-145)(103-104)(103-105)(104-153)(105-163)(106-107)(106-164)(107-108)(108-154)(109-110)(109-112)(110-165)(111-121)(111-166)(112-157)(113-114)(113-143)(114-134)(115-151)(115-167)(116-151)(116-155)(117-152)(117-168)(118-152)(118-156)(119-120)(119-137)(120-148)(121-122)(122-158)(123-124)(123-142)(124-125)(125-140)(126-139)(126-170)(127-128)(127-141)(128-149)(129-140)(130-131)(130-132)(131-138)(132-134)(133-136)(133-150)(135-136)(135-137)(138-139)(141-144)(142-143)(144-145)(146-147)(146-172)(147-150)(148-149)(151-169)(152-171)(153-177)(154-178)(155-179)(156-180)(157-181)(158-182)(159-160)(159-173)(160-174)(161-162)(161-176)(162-175)(163-166)(163-177)(164-165)(164-178)(165-181)(166-182)(167-168)(167-179)(168-180)(169-174)(169-184)(170-173)(170-183)(171-176)(171-185)(172-175)(172-186)(177-187)(178-187)(179-187)(180-187)(181-187)(182-187)

Measurements (9)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
CT-260.26— 10.1021/acsnano.4c17344 2025
HCT-1160.33— 10.1021/acsnano.4c17344 2025
NCI-H19753.7— 10.1021/acsnano.4c17344 2025
MCF-74.1— 10.1021/acsnano.4c17344 2025
HeLa10— 10.1021/acsnano.4c17344 2025
HepG216— 10.1021/acsnano.4c17344 2025
PANC-117— 10.1021/acsnano.4c17344 2025
A54917— 10.1021/acsnano.4c17344 2025
HEK293T20— 10.1021/acsnano.4c17344 2025

🧬 Cell Death Types (2)

Autophagy high
«RuOA2 induces ferritinophagy... the autophagy inhibitor CQ... significantly increased cell viability»
Ferroptosis high
«RuOA2 ruthenosomes effectively induce ferritinophagy-mediated tumor cell death»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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