Info
| ID | 477 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 1 |
| SMILES | C(=C/c1ccnc(-c2cc(/C=C/c3ccccc3)ccn2)c1)\c1ccccc1.C(=C/c1ccnc(-c2cc(/C=C/c3ccccc3)ccn2)c1)\c1ccccc1.C(=C/c1ccnc(-c2cc(/C=C/c3ccccc3)ccn2)c1)\c1ccccc1 |
TUCAN
C78H60N6Ru/(1-66)(2-65)(3-73)(4-68)(5-82)(6-127)(7-61)(8-62)(9-128)(10-70)(11-97)(12-91)(13-63)(14-64)(15-67)(16-69)(17-99)(18-94)(19-71)(20-129)(21-74)(22-98)(23-112)(24-72)(25-76)(26-79)(27-77)(28-78)(29-81)(30-75)(31-80)(32-86)(33-103)(34-84)(35-88)(36-113)(37-83)(38-87)(39-85)(40-93)(41-108)(42-89)(43-90)(44-106)(45-104)(46-95)(47-92)(48-96)(49-110)(50-109)(51-130)(52-101)(53-131)(54-107)(55-114)(56-100)(57-111)(58-102)(59-132)(60-105)(61-65)(61-116)(62-66)(62-115)(63-68)(63-115)(64-69)(64-118)(65-115)(66-75)(67-72)(67-118)(68-75)(69-80)(70-73)(70-117)(71-76)(71-119)(72-80)(73-118)(74-77)(74-119)(76-84)(77-84)(78-81)(78-85)(79-116)(79-133)(81-123)(82-116)(82-127)(83-117)(83-134)(85-86)(86-88)(87-92)(87-93)(88-123)(89-92)(89-96)(90-120)(90-135)(91-117)(91-128)(93-124)(94-120)(94-129)(95-101)(95-102)(96-124)(97-98)(97-119)(98-120)(99-103)(99-123)(100-102)(100-105)(101-125)(103-121)(104-121)(104-136)(105-125)(106-121)(106-130)(107-122)(107-131)(108-112)(108-122)(109-122)(109-137)(110-113)(110-126)(111-126)(111-138)(112-124)(113-125)(114-126)(114-132)(127-139)(128-140)(129-141)(130-142)(131-143)(132-144)(133-134)(133-139)(134-140)(135-137)(135-141)(136-138)(136-142)(137-143)(138-144)(139-145)(140-145)(141-145)(142-145)(143-145)(144-145)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPE-1 | — | 31 | 10.1038/s41467-020-16993-0 | 2020 |
| RPE-1 | — | 32 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 30 | 10.1038/s41467-020-16993-0 | 2020 |
| HeLa | — | 49 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 20 | 10.1038/s41467-020-16993-0 | 2020 |
| CT-26 | — | 33 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 52 | 10.1038/s41467-020-16993-0 | 2020 |
| U373 | — | 83 | 10.1038/s41467-020-16993-0 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»
Paraptosis
high
«While apoptosis was found to be the cell death mechanism for 1 – 5, 6 – 7 triggered cell death by a combination of apoptosis and paraptosis pathways.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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