Info
| ID | 4686 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ru–B |
| SMILES | CC1=CC(C)=[N+]2C1=C(c1ccc(-c3cc(-c4ccccn4)nc(-c4ccccn4)c3)cc1)c1c(C)cc(C)n1[B-]2(F)F.O=C(O)c1ccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)cc1 |
TUCAN
C56H43BF2N8O2Ru/(1-64)(2-45)(3-45)(4-54)(5-72)(6-59)(7-73)(8-57)(9-58)(10-85)(11-49)(12-46)(13-45)(14-70)(15-51)(16-63)(17-62)(18-46)(19-48)(20-48)(21-65)(22-46)(23-52)(24-53)(25-84)(26-66)(27-67)(28-87)(29-86)(30-68)(31-48)(32-71)(33-47)(34-56)(35-55)(36-47)(37-69)(38-60)(39-50)(40-74)(41-61)(42-47)(43-110)(44-103)(44-104)(44-111)(44-112)(45-91)(46-76)(47-79)(48-92)(49-55)(49-56)(50-65)(50-88)(51-82)(51-90)(52-53)(52-83)(53-75)(54-65)(54-85)(55-84)(56-96)(57-58)(57-77)(58-80)(59-63)(59-74)(60-69)(60-77)(61-72)(61-87)(62-72)(62-97)(63-98)(64-76)(64-91)(66-68)(66-75)(67-82)(67-89)(68-83)(69-80)(70-78)(70-99)(71-78)(71-93)(73-79)(73-92)(74-86)(75-82)(76-94)(77-78)(79-95)(80-81)(81-94)(81-95)(83-100)(84-101)(85-105)(86-107)(87-102)(88-90)(88-105)(89-96)(89-108)(90-108)(91-103)(92-104)(93-98)(93-106)(94-103)(95-104)(96-101)(97-99)(97-102)(98-107)(99-106)(100-109)(100-110)(105-113)(106-113)(107-113)(108-113)(110-113)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | — | 0.29 | 10.1021/acs.inorgchem.4c03083 | 2024 |
| MDA-MB-231 | — | 0.55 | 10.1021/acs.inorgchem.4c03083 | 2024 |
| BEAS-2B | — | 1.9 | 10.1021/acs.inorgchem.4c03083 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Cellular apoptosis and alteration of the mitochondrial membrane potential were evidenced from the respective Annexin V-FITC/propidium iodide assay and JC-1 dye assay.»