Info
| ID | 4685 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ru-Me |
| SMILES | COC(=O)/C=C/c1ccc(-c2nccc3c4ccccc4n(C)c23)nc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C41H33N7O2Ru/(1-59)(2-60)(3-58)(4-58)(5-34)(6-61)(7-35)(8-37)(9-58)(10-63)(11-40)(12-36)(13-43)(14-41)(15-38)(16-47)(17-73)(18-50)(19-39)(20-48)(21-45)(22-42)(23-44)(24-62)(25-73)(26-73)(27-49)(28-54)(29-64)(30-53)(31-51)(32-46)(33-52)(34-35)(34-59)(35-36)(36-65)(37-43)(37-60)(38-41)(38-55)(39-48)(39-67)(40-56)(40-63)(41-72)(42-43)(42-66)(44-46)(44-69)(45-46)(45-61)(47-50)(47-55)(48-49)(49-54)(50-74)(51-52)(51-62)(52-53)(53-70)(54-57)(55-64)(56-57)(56-68)(57-67)(58-75)(59-76)(60-77)(61-78)(62-79)(63-80)(64-81)(65-66)(65-76)(66-77)(67-75)(68-71)(68-75)(69-70)(69-78)(70-79)(71-72)(71-80)(72-81)(73-83)(74-82)(74-83)(76-84)(77-84)(78-84)(79-84)(80-84)(81-84)(83-84)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 62 | 44 | 10.1021/acs.inorgchem.4c02583 | 2024 |
| A549 | 75 | 34 | 10.1021/acs.inorgchem.4c02583 | 2024 |
| PC-3 | 77 | 49 | 10.1021/acs.inorgchem.4c02583 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Overall, these results indicated that the photodynamic activity of both the complexes and metallopeptides promotes a regulated cell death by apoptosis.»