Info
| ID | 4684 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ru-H |
| SMILES | Cn1c2ccccc2c2ccnc(-c3ccc(/C=C/C(=O)O)cn3)c21.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C40H31N7O2Ru/(1-32)(2-52)(3-37)(4-60)(5-35)(6-33)(7-34)(8-42)(9-38)(10-57)(11-58)(12-39)(13-50)(14-41)(15-44)(16-43)(17-51)(18-59)(19-40)(20-47)(21-61)(22-56)(23-56)(24-36)(25-62)(26-45)(27-46)(28-48)(29-49)(30-56)(31-80)(32-35)(32-63)(33-39)(33-64)(34-35)(34-57)(36-51)(36-65)(37-41)(37-54)(38-39)(38-58)(40-45)(40-66)(41-44)(42-43)(42-71)(43-55)(44-50)(45-46)(46-59)(47-48)(47-68)(48-49)(49-61)(50-69)(51-55)(52-53)(52-62)(53-54)(53-70)(54-69)(55-60)(56-72)(57-73)(58-74)(59-75)(60-76)(61-77)(62-78)(63-64)(63-73)(64-74)(65-67)(65-76)(66-68)(66-75)(67-70)(67-78)(68-77)(69-72)(70-72)(71-79)(71-80)(73-81)(74-81)(75-81)(76-81)(77-81)(78-81)(80-81)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 54 | 44 | 10.1021/acs.inorgchem.4c02583 | 2024 |
| A549 | 68 | 57 | 10.1021/acs.inorgchem.4c02583 | 2024 |
| PC-3 | 70 | 35 | 10.1021/acs.inorgchem.4c02583 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Overall, these results indicated that the photodynamic activity of both the complexes and metallopeptides promotes a regulated cell death by apoptosis.»