Info
| ID | 4668 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 3 |
| SMILES | COc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.COc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1c[nH]c(-c2ncc[nH]2)n1 |
TUCAN
C46H34N12O2Ru/(1-36)(2-58)(3-37)(4-40)(5-77)(6-39)(7-77)(8-41)(9-44)(10-42)(11-77)(12-60)(13-46)(14-57)(15-50)(16-59)(17-62)(18-48)(19-35)(20-78)(21-47)(22-45)(23-78)(24-78)(25-64)(26-49)(27-61)(28-63)(29-43)(30-38)(31-83)(32-84)(33-85)(34-86)(35-37)(35-52)(36-40)(36-79)(37-60)(38-43)(38-55)(39-47)(39-58)(40-51)(41-44)(41-79)(42-46)(42-80)(43-62)(44-51)(45-48)(45-80)(46-54)(47-53)(48-54)(49-50)(49-56)(50-64)(51-73)(52-66)(52-69)(53-65)(53-68)(54-74)(55-67)(55-72)(56-70)(56-71)(57-59)(57-83)(58-81)(59-90)(60-87)(61-63)(61-92)(62-88)(63-84)(64-82)(65-66)(65-85)(66-89)(67-71)(67-91)(68-69)(68-81)(69-87)(70-72)(70-82)(71-86)(72-88)(73-85)(73-89)(74-86)(74-91)(75-76)(75-83)(75-90)(76-84)(76-92)(77-93)(78-94)(79-93)(80-94)(87-95)(88-95)(89-95)(90-95)(91-95)(92-95)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 32 | — | 10.1039/c3nj00542a | 2013 |
| HepG2 | 59 | — | 10.1039/c3nj00542a | 2013 |
| HeLa | 67 | — | 10.1039/c3nj00542a | 2013 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis and evaluation of mitochondrial membrane potential demonstrated that complex 2 inhibited the growth of HeLa cells through induction of apoptotic cell death.»