Info
| ID | 4621 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | RuIQ-4 |
| SMILES | COc1ccc2ccnc(-c3[c-]cc(F)cc3)c2c1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C36H27FN5ORu/(1-51)(2-36)(3-35)(4-38)(5-52)(6-31)(7-29)(8-37)(9-53)(10-43)(11-54)(12-30)(13-46)(14-55)(15-47)(16-32)(17-42)(18-45)(19-44)(20-61)(21-40)(22-33)(23-34)(24-39)(25-41)(26-61)(27-61)(28-46)(28-48)(29-36)(29-56)(30-38)(30-57)(31-34)(31-63)(32-40)(32-50)(33-49)(33-62)(34-48)(35-36)(35-51)(37-38)(37-52)(39-43)(39-58)(40-62)(41-45)(41-60)(42-43)(42-53)(44-45)(44-54)(46-63)(47-50)(47-55)(48-59)(49-50)(49-59)(51-64)(52-65)(53-67)(54-68)(55-66)(56-57)(56-64)(57-65)(58-60)(58-67)(59-66)(60-68)(61-69)(62-69)(63-70)(64-71)(65-71)(66-71)(67-71)(68-71)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 3.8 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| A549cisR | 4.1 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| MCF-7 | 7.2 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| HepG2 | 7.8 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| HBE | 24 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«RuIQ-5 could induce apoptosis through mitochondrial dysfunction, reactive oxygen species (ROS) accumulation, ROS-mediated DNA damage, and cycle arrest at both S and G2/M phases.»