Info
| ID | 4620 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | RuIQ-3 |
| SMILES | Fc1c[c-]c(-c2nccc3ccccc23)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C35H25FN5Ru/(1-50)(2-27)(3-51)(4-41)(5-33)(6-30)(7-53)(8-52)(9-45)(10-36)(11-28)(12-29)(13-31)(14-32)(15-34)(16-54)(17-46)(18-42)(19-35)(20-37)(21-38)(22-43)(23-39)(24-44)(25-40)(26-46)(26-47)(27-28)(27-33)(28-50)(29-32)(29-51)(30-31)(30-37)(31-53)(32-38)(33-55)(34-39)(34-54)(35-42)(35-48)(36-49)(36-52)(37-57)(38-58)(39-43)(40-42)(40-44)(41-45)(41-60)(43-59)(44-49)(45-47)(46-60)(47-56)(48-49)(48-56)(50-62)(51-63)(52-61)(53-64)(54-65)(55-57)(55-62)(56-61)(57-64)(58-59)(58-63)(59-65)(60-66)(61-67)(62-67)(63-67)(64-67)(65-67)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 4.5 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| A549cisR | 4.9 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| MCF-7 | 7.9 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| HepG2 | 8.4 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
| HBE | 25 | — | 10.1016/j.bioorg.2021.105516 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«RuIQ-5 could induce apoptosis through mitochondrial dysfunction, reactive oxygen species (ROS) accumulation, ROS-mediated DNA damage, and cycle arrest at both S and G2/M phases.»