Info
| ID | 4612 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | 2 |
| SMILES | c1ccc(Cn2c(-c3ccccn3)nc3ccccc32)cc1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C43H31N7Ru/(1-47)(2-55)(3-32)(4-61)(5-33)(6-35)(7-40)(8-36)(9-62)(10-34)(11-38)(12-52)(13-64)(14-39)(15-63)(16-46)(17-41)(18-53)(19-37)(20-42)(21-43)(22-65)(23-49)(24-54)(25-66)(26-50)(27-48)(28-44)(29-51)(30-66)(31-45)(32-49)(32-56)(33-34)(33-61)(34-56)(35-50)(35-58)(36-43)(36-62)(37-40)(37-41)(38-40)(38-57)(39-47)(39-55)(41-45)(42-44)(42-64)(43-58)(44-59)(45-57)(46-53)(46-63)(47-71)(48-51)(48-65)(49-59)(50-60)(51-60)(52-55)(52-72)(53-54)(54-68)(56-67)(57-66)(58-69)(59-70)(60-73)(61-76)(62-77)(63-81)(64-78)(65-79)(66-75)(67-70)(67-76)(68-74)(68-81)(69-73)(69-77)(70-78)(71-72)(71-80)(72-75)(73-79)(74-75)(74-80)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 3.2e+02 | — | 10.1007/s11243-019-00341-3 | 2022 |
| Vero | 3.6e+02 | — | 10.1007/s11243-019-00341-3 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Furthermore, gene expression studies on BAX and BCL-2 genes and FACS analysis confirmed apoptosis as the mode of cell death.»