Info
| ID | 4594 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 4-2 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]c1cccc2ccc(C=Cc3ccc(Cl)cc3)nc12 |
TUCAN
C27Cl2NORu/(1-20)(2-22)(3-22)(4-16)(4-23)(5-7)(5-20)(6-14)(6-25)(7-19)(8-13)(8-19)(9-10)(9-21)(10-27)(11-18)(11-27)(12-15)(12-17)(13-20)(14-21)(15-26)(16-25)(17-23)(18-21)(19-22)(23-24)(24-26)(24-28)(25-28)(26-29)(27-31)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 0.75 | — | 10.1039/d2dt03317h | 2023 |
| LO2 | 4.7 | — | 10.1039/d2dt03317h | 2023 |
| A549 | 5.1 | — | 10.1039/d2dt03317h | 2023 |
| MCF-7 | 5.6 | — | 10.1039/d2dt03317h | 2023 |
| MDA-MB-231 | 6.2 | — | 10.1039/d2dt03317h | 2023 |
| HepG2 | 7 | — | 10.1039/d2dt03317h | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The damage of lysosomes promotes the release of cathepsin B and initiates downstream apoptotic cascade signals.»