Info
| ID | 4593 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 4-1 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]c1cccc2ccc(C=Cc3ccc(F)cc3)nc12 |
TUCAN
C27ClFNORu/(1-20)(2-22)(3-22)(4-15)(4-23)(5-7)(5-20)(6-13)(6-25)(7-19)(8-12)(8-19)(9-16)(9-27)(10-18)(10-27)(11-14)(11-17)(12-20)(13-21)(14-26)(15-25)(16-21)(17-23)(18-21)(19-22)(23-24)(24-26)(24-28)(25-28)(26-29)(27-30)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 5.4 | — | 10.1039/d2dt03317h | 2023 |
| HeLa | 6.7 | — | 10.1039/d2dt03317h | 2023 |
| A549 | 7.5 | — | 10.1039/d2dt03317h | 2023 |
| MCF-7 | 10 | — | 10.1039/d2dt03317h | 2023 |
| HepG2 | 10 | — | 10.1039/d2dt03317h | 2023 |
| LO2 | 11 | — | 10.1039/d2dt03317h | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The damage of lysosomes promotes the release of cathepsin B and initiates downstream apoptotic cascade signals.»