Info
| ID | 4592 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 1, "P": 2} |
| Abbreviation | (3) |
| SMILES | CN(C)C(=S)N=C([O-])c1cccs1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2Oc2ccccc2P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C54H45N4O2P2RuS2/(1-46)(2-50)(3-53)(4-51)(5-47)(6-48)(7-49)(8-54)(9-55)(10-71)(11-63)(12-84)(13-85)(14-74)(15-75)(16-78)(17-81)(18-76)(19-77)(20-56)(21-65)(22-57)(23-69)(24-59)(25-61)(26-80)(27-97)(28-79)(29-82)(30-58)(31-62)(32-64)(33-52)(34-66)(35-70)(36-72)(37-60)(38-73)(39-67)(40-68)(41-82)(42-82)(43-83)(44-83)(45-83)(46-47)(46-50)(47-92)(48-51)(48-92)(49-52)(49-91)(50-51)(52-60)(53-54)(53-63)(54-55)(55-93)(56-65)(56-69)(57-63)(57-93)(58-60)(58-88)(59-65)(59-94)(61-69)(61-94)(62-72)(62-95)(64-67)(64-89)(66-73)(66-95)(67-68)(68-71)(70-72)(70-73)(71-96)(74-75)(74-84)(75-78)(76-77)(76-81)(77-85)(78-86)(79-80)(79-97)(80-98)(81-87)(82-100)(83-100)(84-102)(85-103)(86-87)(86-102)(87-103)(88-91)(88-105)(89-96)(89-105)(90-98)(90-101)(90-104)(91-106)(92-106)(93-106)(94-107)(95-107)(96-107)(97-109)(98-109)(99-100)(99-101)(99-108)(101-110)(102-110)(103-110)(105-110)(106-110)(107-110)(109-110)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.11 | — | 10.1039/d1dt02851k | 2022 |
| MDA-MB-231 | 0.13 | — | 10.1039/d1dt02851k | 2022 |
| MRC-5 | 0.23 | — | 10.1039/d1dt02851k | 2022 |
| MCF-10A | 0.38 | — | 10.1039/d1dt02851k | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Investigations of the mechanism of action of complex 1 in A549 cells demonstrated that it inhibits colony formation and promotes cell cycle arrest in the G1 phase and apoptotic cell death.»