Info
| ID | 4591 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 1, "P": 2} |
| Abbreviation | (2) |
| SMILES | CN(C)C(=S)N=C([O-])c1ccco1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2Oc2ccccc2P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C54H45N4O3P2RuS/(1-52)(2-51)(3-54)(4-55)(5-60)(6-46)(7-62)(8-61)(9-49)(10-65)(11-58)(12-84)(13-85)(14-48)(15-47)(16-76)(17-80)(18-64)(19-66)(20-56)(21-74)(22-57)(23-63)(24-81)(25-88)(26-78)(27-82)(28-53)(29-68)(30-70)(31-69)(32-71)(33-75)(34-50)(35-73)(36-72)(37-59)(38-67)(39-82)(40-82)(41-79)(42-83)(43-83)(44-77)(45-83)(46-52)(46-93)(47-48)(47-76)(48-84)(49-55)(49-93)(50-53)(50-94)(51-52)(51-55)(53-62)(54-60)(54-61)(56-60)(56-95)(57-61)(57-95)(58-65)(58-66)(59-62)(59-89)(63-65)(63-96)(64-74)(64-75)(66-68)(67-70)(67-90)(68-96)(69-74)(69-97)(70-71)(71-73)(72-75)(72-97)(73-98)(76-86)(77-79)(77-85)(78-81)(78-88)(79-80)(80-87)(81-91)(82-100)(83-100)(84-102)(85-103)(86-87)(86-102)(87-103)(88-106)(89-94)(89-105)(90-98)(90-105)(91-92)(91-106)(92-101)(92-104)(93-107)(94-107)(95-107)(96-108)(97-108)(98-108)(99-100)(99-101)(99-109)(101-110)(102-110)(103-110)(105-110)(106-110)(107-110)(108-110)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.07 | — | 10.1039/d1dt02851k | 2022 |
| MDA-MB-231 | 0.11 | — | 10.1039/d1dt02851k | 2022 |
| MRC-5 | 0.33 | — | 10.1039/d1dt02851k | 2022 |
| MCF-10A | 0.33 | — | 10.1039/d1dt02851k | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Investigations of the mechanism of action of complex 1 in A549 cells demonstrated that it inhibits colony formation and promotes cell cycle arrest in the G1 phase and apoptotic cell death.»