Info
| ID | 4590 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 1, "P": 2} |
| Abbreviation | (1) |
| SMILES | CN(C)C(=S)N=C([O-])c1ccccc1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2Oc2ccccc2P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C56H47N4O2P2RuS/(1-50)(2-54)(3-49)(4-48)(5-55)(6-59)(7-71)(8-53)(9-51)(10-90)(11-91)(12-57)(13-56)(14-79)(15-84)(16-86)(17-78)(18-65)(19-52)(20-58)(21-60)(22-63)(23-62)(24-80)(25-85)(26-66)(27-67)(28-69)(29-64)(30-68)(31-61)(32-72)(33-75)(34-70)(35-73)(36-76)(37-74)(38-77)(39-88)(40-88)(41-88)(42-83)(43-82)(44-89)(45-81)(46-89)(47-89)(48-50)(48-54)(49-50)(49-98)(51-54)(51-98)(52-55)(52-99)(53-55)(53-59)(56-57)(56-79)(57-90)(58-62)(58-64)(59-60)(60-99)(61-69)(61-71)(62-63)(63-101)(64-67)(65-69)(65-97)(66-75)(66-100)(67-101)(68-70)(68-73)(70-72)(71-94)(72-76)(73-102)(74-75)(74-77)(76-102)(77-95)(78-80)(78-86)(79-92)(80-87)(81-83)(81-91)(82-85)(82-87)(83-84)(84-93)(85-86)(87-96)(88-104)(89-104)(90-106)(91-107)(92-93)(92-106)(93-107)(94-97)(94-109)(95-100)(95-109)(96-105)(96-108)(97-110)(98-110)(99-110)(100-111)(101-111)(102-111)(103-104)(103-105)(103-112)(105-113)(106-113)(107-113)(109-113)(110-113)(111-113)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.09 | — | 10.1039/d1dt02851k | 2022 |
| MDA-MB-231 | 0.1 | — | 10.1039/d1dt02851k | 2022 |
| MCF-10A | 0.55 | — | 10.1039/d1dt02851k | 2022 |
| MRC-5 | 0.7 | — | 10.1039/d1dt02851k | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Investigations of the mechanism of action of complex 1 in A549 cells demonstrated that it inhibits colony formation and promotes cell cycle arrest in the G1 phase and apoptotic cell death.»