Info
| ID | 4543 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1} |
| Abbreviation | Complex 3 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C([O-])c1cc(-c2ccc(F)cc2F)ccc1O.[Cl-] |
TUCAN
C23ClF2O3Ru/(1-16)(2-14)(3-14)(4-6)(4-17)(5-15)(5-19)(6-16)(7-10)(7-19)(8-12)(8-17)(9-13)(9-18)(10-20)(11-22)(11-23)(12-16)(13-22)(14-17)(15-20)(15-21)(18-19)(18-23)(20-26)(21-24)(21-25)(22-28)(23-27)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 62 | — | 10.1021/acsabm.0c00501 | 2020 |
| HEK293 | 63 | — | 10.1021/acsabm.0c00501 | 2020 |
| A549 | 72 | — | 10.1021/acsabm.0c00501 | 2020 |
| HeLa | — | — | 10.1021/acsabm.0c00501 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«It was found that these complexes show anticancer properties through apoptosis which was confirmed by Hoechst PI staining. (Conclusion) Also, 'confirming the changes in morphology are in association w...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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