Info
| ID | 4542 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | Complex 2 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C([O-])c1ccccc1Nc1cccc(C(F)(F)F)c1.[Cl-] |
TUCAN
C24ClF3NO2Ru/(1-17)(2-16)(3-17)(4-7)(4-20)(5-10)(5-19)(6-7)(6-9)(8-14)(8-21)(9-22)(10-16)(11-12)(11-16)(12-19)(13-14)(13-18)(15-18)(15-21)(17-19)(18-24)(20-22)(20-23)(21-25)(22-25)(23-26)(23-27)(24-28)(24-29)(24-30)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 12 | — | 10.1021/acsabm.0c00501 | 2020 |
| HeLa | 52 | — | 10.1021/acsabm.0c00501 | 2020 |
| A549 | 59 | — | 10.1021/acsabm.0c00501 | 2020 |
| HEK293 | 64 | — | 10.1021/acsabm.0c00501 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«It was found that these complexes show anticancer properties through apoptosis which was confirmed by Hoechst PI staining. (Conclusion) Also, 'confirming the changes in morphology are in association w...»