Info
| ID | 454 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3, "P": 1, "O": 1} |
| Abbreviation | 8 |
| SMILES | C1N2CN3CN1CP(C2)C3.Cc1ccc(C(C)C)cc1.O=C(/C=C(\[O-])C(F)(F)F)c1ccc(Cl)cc1 |
TUCAN
C26ClF3N3O2PRu/(1-13)(2-13)(3-14)(4-10)(4-15)(5-20)(5-21)(6-7)(6-16)(7-14)(8-9)(8-16)(9-14)(10-26)(11-12)(11-15)(12-26)(13-16)(15-20)(17-27)(17-28)(18-27)(18-29)(19-28)(19-29)(20-30)(21-22)(21-31)(22-32)(22-33)(22-34)(23-27)(23-35)(24-28)(24-35)(25-29)(25-35)(26-36)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 18 | — | 10.3390/ph14060518 | 2021 |
| COLO-320 | 48 | — | 10.3390/ph14060518 | 2021 |
| COLO-205 | 81 | — | 10.3390/ph14060518 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 5 was also reported to be cytotoxic against a series of human cancer cells and induced caspase-dependent cell death in leukemia cells [17].»