Info
| ID | 4534 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "P": 1} |
| Abbreviation | 2b |
| SMILES | CCCCN(CCCC)CP(c1ccccc1)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C31Cl2NPRu/(1-11)(2-24)(3-24)(4-16)(5-26)(6-7)(6-25)(7-26)(8-10)(8-29)(9-23)(9-25)(10-12)(11-14)(12-13)(13-15)(14-27)(15-29)(16-20)(17-18)(17-30)(18-21)(19-21)(19-22)(20-28)(22-30)(23-26)(24-25)(27-32)(28-32)(29-33)(30-33)(31-32)(31-33)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 14 | — | 10.3390/ph15020169 | 2022 |
| DU-145 | 17 | — | 10.3390/ph15020169 | 2022 |
| PANC-1 | 1.1e+02 | — | 10.3390/ph15020169 | 2022 |
| MCF-7 | 1.2e+02 | — | 10.3390/ph15020169 | 2022 |
| HaCaT | 3.5e+02 | — | 10.3390/ph15020169 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«For Ru(II) compounds treated cells, the lower toxicity (more live cells) and mainly apoptotic cells are observed (up to 58%).»