Info
| ID | 4533 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "P": 1} |
| Abbreviation | 1b |
| SMILES | CCN(CC)CP(c1ccccc1)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C27Cl2NPRu/(1-20)(2-20)(3-23)(4-22)(5-24)(6-7)(6-21)(7-22)(8-19)(8-21)(9-11)(9-12)(10-12)(10-14)(11-25)(13-15)(13-18)(14-25)(15-26)(16-17)(16-18)(17-26)(19-22)(20-21)(23-28)(24-28)(25-29)(26-29)(27-28)(27-29)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 10 | — | 10.3390/ph15020169 | 2022 |
| DU-145 | 23 | — | 10.3390/ph15020169 | 2022 |
| PANC-1 | 1.3e+02 | — | 10.3390/ph15020169 | 2022 |
| MCF-7 | 1.4e+02 | — | 10.3390/ph15020169 | 2022 |
| HaCaT | 3e+02 | — | 10.3390/ph15020169 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«For Ru(II) compounds treated cells, the lower toxicity (more live cells) and mainly apoptotic cells are observed (up to 58%).»