Info
| ID | 4528 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 1} |
| Abbreviation | 4 |
| SMILES | COc1ccc(/N=C/c2cccc(OC)c2[O-])cc1OC.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C26H30NO4Ru/(1-35)(2-34)(3-31)(4-32)(5-31)(6-32)(7-37)(8-31)(9-33)(10-32)(11-47)(12-33)(13-33)(14-36)(15-39)(16-40)(17-43)(18-38)(19-52)(20-52)(21-52)(22-48)(23-41)(24-42)(25-51)(26-50)(27-51)(28-51)(29-50)(30-50)(31-47)(32-45)(33-47)(34-35)(34-45)(35-44)(36-39)(36-44)(37-49)(37-54)(38-43)(38-46)(39-45)(40-43)(40-56)(41-42)(41-49)(42-55)(44-47)(46-48)(46-53)(48-57)(49-57)(50-60)(51-59)(52-61)(53-56)(53-58)(54-55)(54-60)(55-61)(56-59)(57-62)(61-62)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 19 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
| MIA PaCa-2 | 20 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
| HepG2 | 24 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both 1 and 3 induced apoptosis as per the Annexin-V/PE and 7AAD double-staining assay in MDA-MB-231 cells. The IC50 as well as the sub-IC50 dose showed that cell killing occurs through apoptosis. 1 in...»