Info
| ID | 4527 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 1} |
| Abbreviation | 3 |
| SMILES | COc1cccc(/C=N/c2cc(OC)c(OC)c(OC)c2)c1[O-].Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C27H32NO5Ru/(1-33)(2-37)(3-34)(4-52)(5-39)(6-34)(7-48)(8-34)(9-33)(10-35)(11-36)(12-33)(13-40)(14-35)(15-38)(16-35)(17-51)(18-44)(19-49)(20-53)(21-53)(22-53)(23-41)(24-42)(25-43)(26-51)(27-51)(28-54)(29-52)(30-54)(31-54)(32-52)(33-45)(34-48)(35-48)(36-37)(36-46)(37-45)(38-40)(38-45)(39-50)(39-56)(40-46)(41-42)(41-47)(42-43)(43-58)(44-50)(44-59)(46-48)(47-49)(47-57)(49-60)(50-60)(51-63)(52-62)(53-65)(54-64)(55-56)(55-59)(55-62)(56-63)(57-58)(57-61)(58-65)(59-64)(60-66)(65-66)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MIA PaCa-2 | 15 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
| MDA-MB-231 | 17 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
| HepG2 | 17 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both 1 and 3 induced apoptosis as per the Annexin-V/PE and 7AAD double-staining assay in MDA-MB-231 cells. The IC50 as well as the sub-IC50 dose showed that cell killing occurs through apoptosis. 1 in...»