Info
| ID | 4525 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 1} |
| Abbreviation | 1 |
| SMILES | COc1cc(/N=C/c2ccccc2[O-])cc(OC)c1OC.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C26H30NO4Ru/(1-34)(2-35)(3-31)(4-33)(5-31)(6-33)(7-51)(8-50)(9-47)(10-31)(11-32)(12-32)(13-33)(14-32)(15-36)(16-39)(17-43)(18-38)(19-37)(20-52)(21-52)(22-52)(23-41)(24-48)(25-42)(26-40)(27-50)(28-51)(29-51)(30-50)(31-47)(32-47)(33-45)(34-35)(34-44)(35-45)(36-39)(36-44)(37-38)(37-41)(38-43)(39-45)(40-49)(40-54)(41-46)(42-49)(42-55)(43-56)(44-47)(46-48)(46-56)(48-57)(49-57)(50-60)(51-59)(52-61)(53-54)(53-55)(53-60)(54-59)(55-61)(56-58)(57-62)(61-62)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MIA PaCa-2 | 9.8 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
| MDA-MB-231 | 11 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
| HepG2 | 14 | — | 10.1021/acs.inorgchem.9b00853 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both 1 and 3 induced apoptosis as per the Annexin-V/PE and 7AAD double-staining assay in MDA-MB-231 cells. The IC50 as well as the sub-IC50 dose showed that cell killing occurs through apoptosis. 1 in...»