Info
| ID | 4523 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 3 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]c1ccccc1/C=N/CCc1ccc(O)cc1 |
TUCAN
C25H28NO2Ru/(1-32)(2-50)(3-51)(4-29)(5-30)(6-35)(7-49)(8-29)(9-34)(10-39)(11-51)(12-44)(13-44)(14-43)(15-33)(16-42)(17-38)(18-40)(19-30)(20-29)(21-30)(22-36)(23-31)(24-37)(25-31)(26-31)(27-41)(28-56)(29-46)(30-49)(31-49)(32-33)(32-43)(33-45)(34-39)(34-52)(35-36)(35-46)(36-47)(37-41)(37-47)(38-40)(38-52)(39-48)(40-48)(41-46)(42-43)(42-53)(44-48)(44-51)(45-50)(45-53)(47-49)(50-54)(51-54)(52-56)(53-55)(54-57)(56-57)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 42 | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
| HFF-1 | 54 | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
| MIA PaCa-2 | 56 | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
| HepG2 | 58 | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Annexin V-PE/7-AAD double staining assay using two different dosages (20 and 35 μM) of 2 showed that there is 31% and 42% apoptosis, respectively, compared to 0.9% in the control. Additionally, the ar...»