Info
| ID | 4521 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 1 |
| SMILES | Cc1ccc(C(C)C)cc1.Oc1ccc(CC/N=C/c2ccccn2)cc1.[Cl-] |
TUCAN
C24H28N2ORu/(1-37)(2-43)(3-50)(4-29)(5-47)(6-34)(7-35)(8-29)(9-39)(10-32)(11-43)(12-41)(13-38)(14-48)(15-49)(16-36)(17-50)(18-40)(19-30)(20-33)(21-30)(22-30)(23-31)(24-31)(25-42)(26-29)(27-31)(28-55)(29-45)(30-47)(31-47)(32-36)(32-48)(33-34)(33-45)(34-46)(35-42)(35-46)(36-38)(37-39)(37-44)(38-51)(39-52)(40-41)(40-44)(41-52)(42-45)(43-44)(43-50)(46-47)(48-54)(49-51)(49-53)(50-53)(51-54)(52-55)(53-56)(54-56)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | — | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
| HepG2 | — | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
| MIA PaCa-2 | — | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
| HFF-1 | — | — | 10.1021/acs.inorgchem.0c00694 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Annexin V-PE/7-AAD double staining assay using two different dosages (20 and 35 μM) of 2 showed that there is 31% and 42% apoptosis, respectively, compared to 0.9% in the control. Additionally, the ar...»