Info
| ID | 451 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 5 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]c1c(I)cc(Cl)c2cccnc12 |
TUCAN
C19Cl2INORu/(1-12)(2-11)(3-11)(4-5)(4-12)(5-13)(6-10)(6-12)(7-8)(7-15)(8-14)(9-18)(9-19)(10-13)(11-13)(14-16)(14-18)(15-20)(16-17)(16-20)(17-19)(17-21)(18-23)(19-25)
Measurements (16)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 3 | — | 10.3390/ph14060518 | 2021 |
| SK-OV-3 | 3.2 | — | 10.1039/c9dt00866g | 2019 |
| HeLa | 4.4 | — | 10.1039/c9dt00866g | 2019 |
| NCI-H460 | 5.6 | — | 10.1021/acs.organomet.5b00868 | 2015 |
| HCT-116 | 7.7 | — | 10.1021/acs.organomet.5b00868 | 2015 |
| Caco-2 | 8.2 | — | 10.1016/j.jphotobiol.2017.11.0... | 2018 |
| MCF-7 | 8.4 | — | 10.1016/j.jphotobiol.2017.11.0... | 2018 |
| SiHa | 8.5 | — | 10.1021/acs.organomet.5b00868 | 2015 |
| HeLa | 9 | — | 10.1016/j.jphotobiol.2017.11.0... | 2018 |
| COLO-320 | 14 | — | 10.3390/ph14060518 | 2021 |
| HIO80 | 14 | — | 10.3389/fphar.2022.920379 | 2022 |
| COV362 | 18 | — | 10.3389/fphar.2022.920379 | 2022 |
| T24 | 21 | — | 10.1039/c9dt00866g | 2019 |
| COLO-205 | 21 | — | 10.3390/ph14060518 | 2021 |
| OVCAR-4 | 28 | — | 10.3389/fphar.2022.920379 | 2022 |
| HL-7702 | 86 | — | 10.1039/c9dt00866g | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 5 was also reported to be cytotoxic against a series of human cancer cells and induced caspase-dependent cell death in leukemia cells [17].»