Info
| ID | 450 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "P": 1, "O": 1} |
| Abbreviation | 4 |
| SMILES | C1N2CN3CN1CP(C2)C3.Cc1ccc(C(C)C)cc1.[O-]n1ccc2ccccc2c1=S |
TUCAN
C25N4OPRuS/(1-17)(2-17)(3-15)(4-6)(4-15)(5-7)(5-11)(6-16)(7-13)(8-9)(8-16)(9-15)(10-11)(10-14)(12-13)(12-18)(13-14)(14-25)(16-17)(18-29)(19-26)(19-27)(20-26)(20-28)(21-27)(21-28)(22-26)(22-31)(23-27)(23-31)(24-28)(24-31)(25-29)(25-32)(29-30)
Measurements (11)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 81 | — | 10.3390/ph14060518 | 2021 |
| COLO-205 | — | — | 10.3390/ph14060518 | 2021 |
| COLO-320 | — | — | 10.3390/ph14060518 | 2021 |
| A2780 | — | — | 10.3390/cancers13102493 | 2021 |
| A549 | — | — | 10.3390/cancers13102493 | 2021 |
| HCT-116 | — | — | 10.3390/cancers13102493 | 2021 |
| OE19 | — | — | 10.3390/cancers13102493 | 2021 |
| HepG2 | — | — | 10.3390/cancers13102493 | 2021 |
| PC-3 | — | — | 10.3390/cancers13102493 | 2021 |
| SK-OV-3 | — | — | 10.3390/cancers13102493 | 2021 |
| SW626 | — | — | 10.3390/cancers13102493 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 5 was also reported to be cytotoxic against a series of human cancer cells and induced caspase-dependent cell death in leukemia cells [17].»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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