Info
| ID | 449 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 3 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]n1ccc2ccccc2c1=S |
TUCAN
C19ClNORuS/(1-14)(2-13)(3-13)(4-9)(4-15)(5-6)(5-17)(6-12)(7-12)(7-16)(8-16)(8-18)(9-14)(10-11)(10-15)(11-14)(13-15)(16-17)(17-19)(18-20)(19-20)(19-22)(20-21)
Measurements (13)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 1 | — | 10.3390/cancers13102493 | 2021 |
| A2780cisR | 1.1 | — | 10.3390/cancers13102493 | 2021 |
| A2780/ADR | 1.6 | — | 10.3390/cancers13102493 | 2021 |
| SW626 | 3.8 | — | 10.3390/cancers13102493 | 2021 |
| A549 | 4.5 | — | 10.3390/cancers13102493 | 2021 |
| PC-3 | 5.1 | — | 10.3390/cancers13102493 | 2021 |
| SK-OV-3 | 6.4 | — | 10.3390/cancers13102493 | 2021 |
| MRC-5 | 7.6 | — | 10.3390/ph14060518 | 2021 |
| COLO-320 | 11 | — | 10.3390/ph14060518 | 2021 |
| OE19 | 11 | — | 10.3390/cancers13102493 | 2021 |
| HCT-116 | 14 | — | 10.3390/cancers13102493 | 2021 |
| COLO-205 | 17 | — | 10.3390/ph14060518 | 2021 |
| HepG2 | 30 | — | 10.3390/cancers13102493 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 5 was also reported to be cytotoxic against a series of human cancer cells and induced caspase-dependent cell death in leukemia cells [17].»