Info
| ID | 4480 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | MA-bip-Ru |
| SMILES | Cc1ccnc(-c2cc(CNC(=O)c3ccccc3Nc3c(Cl)ccc(C)c3Cl)ccn2)c1.[Cl-].c1ccc(-c2ccccc2)cc1 |
TUCAN
C38H32Cl2N4ORu/(1-35)(2-45)(3-40)(4-46)(5-38)(6-49)(7-36)(8-63)(9-34)(10-37)(11-41)(12-39)(13-61)(14-47)(15-33)(16-42)(17-43)(18-34)(19-48)(20-34)(21-33)(22-63)(23-51)(24-52)(25-62)(26-33)(27-44)(28-53)(29-54)(30-50)(31-71)(32-72)(33-57)(34-59)(35-57)(35-66)(36-38)(36-55)(37-41)(37-55)(38-40)(39-43)(39-56)(40-41)(42-48)(42-56)(43-49)(44-57)(44-62)(45-47)(45-59)(46-60)(46-61)(47-69)(48-49)(50-60)(50-67)(51-54)(51-65)(52-53)(52-54)(53-58)(55-56)(58-65)(58-68)(59-70)(60-63)(61-73)(62-74)(63-72)(64-69)(64-70)(64-71)(65-71)(66-67)(66-74)(67-73)(68-72)(68-75)(69-77)(70-76)(73-78)(74-78)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| K-562 | 19 | — | 10.1039/d3dt00282a | 2023 |
| NB4 | 24 | — | 10.1039/d3dt00282a | 2023 |
| MDA-MB-231 | 25 | — | 10.1039/d3dt00282a | 2023 |
| MCF-7 | 27 | — | 10.1039/d3dt00282a | 2023 |
| HLF | — | — | 10.1039/d3dt00282a | 2023 |
🧬 Cell Death Types (1)
Autophagy
high
«MA-bpy-Ru showed significantly high selectivity and cytotoxicity towards MCF-7 cells through the autophagic pathway»